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Antiresorptive treatments primarily target osteoclasts, reducing their lifespan or activity; they may have secondary effects on osteoblasts or osteocytes ().
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My bone density was first tested five years ago when I was 55.
Boa noite, fui orientada a fazer uso do Aclasta por estar com OSTEOPOROSE coluna lombar L5 - S1 e osteopenia no fêmur.
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The onset of ONJ is linked with the temporary or permanent loss of blood to bone tissue, leading to death of the tissue and the eventual collapse of the bone, resulting in knee, ankle, shoulder or hip bone degeneration.
If blood calcium levels are low before receiving denosumab, the low calcium level must be corrected before giving the medicine or it will get worse.
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Hi, I had a DEXA scan bone density test in December of 2012.
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These investigators examined if treatment with zoledronic acid, in addition to standard adjuvant therapy, would improve disease outcomes in such patients.
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High prevalence and correlates of low bone mineral density in young adults with sickle cell disease.
Adverse effects of bisphosphonates.
My understanding is that bisphosphonates have a very high affinity for bone and they work mainly by inhibiting an enzyme that is necessary for osteoclasts, so essentially they inhibit osteoclast action in breaking down bone.
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JAMA Internal Medicine adds to the evidence that this strategy, while improving bone mineral density, may not reduce and may even worsen fractures.
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McClung MR, Geusens P, Miller PD, et al.
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An Update Committee reviewed the literature and re-evaluated previous recommendations.
In addition, the study itself was funded by these drug companies.
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Use of oral bisphosphonates and risk of venous thromboembolism: a population-based case-control study.
Duration of anti-resorptive effects of low dose zoledronate in osteopenic postmenopausal women: A randomized, placebo-controlled trial.
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Oregon Health and Science University, for her independent statistical review of data for this trial, and the late Roger Boonen for his inspiration and support.
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These researchers could not find any article that described the use of bisphosphonates in such lesions or the response to bisphosphonates clinically, on laboratory parameters or imaging.
The interaction between RANK and RANKL is integral to normal bone resorption process.
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Figure 2 Incidence of Fractures during the 3-Year Study Period.
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En general, los resultados ofrecen la confirmación preclínica de la eficacia y la seguridad ósea del ácido zoledrónico administrado en dosis clínicamente relevantes.
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Avoid invasive dental procedures during denosumab treatment.
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